Synphilin suppresses α‐synuclein neurotoxicity in a Parkinson's disease Drosophila model
Identifieur interne : 000143 ( Main/Exploration ); précédent : 000142; suivant : 000144Synphilin suppresses α‐synuclein neurotoxicity in a Parkinson's disease Drosophila model
Auteurs : René Hernández- Vargas [Mexique] ; Luis Fonseca- Ornelas [Mexique] ; Ignacio L Pez- González [Mexique] ; Juan Riesgo- Escovar [Mexique] ; Mario Zurita [Mexique] ; Enrique Reynaud [Mexique]Source :
- genesis [ 1526-954X ] ; 2011-05.
English descriptors
- KwdEn :
Abstract
Parkinson's disease (PD) is the second most common neurodegenerative disorder in humans. It affects 1% of the population over 65‐years old. Its causes are environmental and genetic. As the world population ages, there is an urgent need for better and more detailed animal models for this kind of disease. In this work we show that the use of transgenic Drosophila is comparable to more complicated and costly animal models such as mice. The Drosophila model behaves very similar to the equivalent transgenic mice model. We show that both Synphilin‐1 and α‐synuclein are toxic by themselves, but when co‐expressed, they suppress their toxicity reciprocally. Importantly, the symptoms induced in the fly can be treated and partially reverted using standard PD pharmacological treatments. This work showcases Drosophila as a detailed and multifaceted model for Parkinson's disease, providing a convenient platform in which to study and find new genetic modifiers of PD. genesis 49:392–402, 2011. © 2011 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/dvg.20740
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Synphilin suppresses α‐synuclein neurotoxicity in a Parkinson's disease Drosophila model</title><author><name sortKey="Vargas, Rene Hernandez" sort="Vargas, Rene Hernandez" uniqKey="Vargas R" first="René Hernández-" last="Vargas">René Hernández- Vargas</name></author><author><name sortKey="Ornelas, Luis Fonseca" sort="Ornelas, Luis Fonseca" uniqKey="Ornelas L" first="Luis Fonseca-" last="Ornelas">Luis Fonseca- Ornelas</name></author><author><name sortKey="Gonzalez, Ignacio L Pez" sort="Gonzalez, Ignacio L Pez" uniqKey="Gonzalez I" first="Ignacio L Pez-" last="González">Ignacio L Pez- González</name></author><author><name sortKey="Escovar, Juan Riesgo" sort="Escovar, Juan Riesgo" uniqKey="Escovar J" first="Juan Riesgo-" last="Escovar">Juan Riesgo- Escovar</name></author><author><name sortKey="Zurita, Mario" sort="Zurita, Mario" uniqKey="Zurita M" first="Mario" last="Zurita">Mario Zurita</name></author><author><name sortKey="Reynaud, Enrique" sort="Reynaud, Enrique" uniqKey="Reynaud E" first="Enrique" last="Reynaud">Enrique Reynaud</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:422509D73063BA42E12C834111AAF272F7C3E0C7</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/dvg.20740</idno><idno type="url">https://api.istex.fr/document/422509D73063BA42E12C834111AAF272F7C3E0C7/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001401</idno><idno type="wicri:Area/Main/Curation">001187</idno><idno type="wicri:Area/Main/Exploration">000143</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Synphilin suppresses α‐synuclein neurotoxicity in a Parkinson's disease Drosophila model</title><author><name sortKey="Vargas, Rene Hernandez" sort="Vargas, Rene Hernandez" uniqKey="Vargas R" first="René Hernández-" last="Vargas">René Hernández- Vargas</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca</wicri:regionArea><wicri:noRegion>Cuernavaca</wicri:noRegion></affiliation></author><author><name sortKey="Ornelas, Luis Fonseca" sort="Ornelas, Luis Fonseca" uniqKey="Ornelas L" first="Luis Fonseca-" last="Ornelas">Luis Fonseca- Ornelas</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca</wicri:regionArea><wicri:noRegion>Cuernavaca</wicri:noRegion></affiliation></author><author><name sortKey="Gonzalez, Ignacio L Pez" sort="Gonzalez, Ignacio L Pez" uniqKey="Gonzalez I" first="Ignacio L Pez-" last="González">Ignacio L Pez- González</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca</wicri:regionArea><wicri:noRegion>Cuernavaca</wicri:noRegion></affiliation></author><author><name sortKey="Escovar, Juan Riesgo" sort="Escovar, Juan Riesgo" uniqKey="Escovar J" first="Juan Riesgo-" last="Escovar">Juan Riesgo- Escovar</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiología, Campus UNAM‐Juriquilla, Universidad Nacional Autónoma de México, Querétaro</wicri:regionArea><wicri:noRegion>Querétaro</wicri:noRegion></affiliation></author><author><name sortKey="Zurita, Mario" sort="Zurita, Mario" uniqKey="Zurita M" first="Mario" last="Zurita">Mario Zurita</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca</wicri:regionArea><wicri:noRegion>Cuernavaca</wicri:noRegion></affiliation></author><author><name sortKey="Reynaud, Enrique" sort="Reynaud, Enrique" uniqKey="Reynaud E" first="Enrique" last="Reynaud">Enrique Reynaud</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca</wicri:regionArea><wicri:noRegion>Cuernavaca</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">genesis</title><title level="j" type="abbrev">Genesis</title><idno type="ISSN">1526-954X</idno><idno type="eISSN">1526-968X</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-05">2011-05</date><biblScope unit="volume">49</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="392">392</biblScope><biblScope unit="page" to="402">402</biblScope></imprint><idno type="ISSN">1526-954X</idno></series><idno type="istex">422509D73063BA42E12C834111AAF272F7C3E0C7</idno><idno type="DOI">10.1002/dvg.20740</idno><idno type="ArticleID">DVG20740</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1526-954X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Lewy bodies</term><term>amyloid</term><term>animal model</term><term>neurodegenerative disease</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is the second most common neurodegenerative disorder in humans. It affects 1% of the population over 65‐years old. Its causes are environmental and genetic. As the world population ages, there is an urgent need for better and more detailed animal models for this kind of disease. In this work we show that the use of transgenic Drosophila is comparable to more complicated and costly animal models such as mice. The Drosophila model behaves very similar to the equivalent transgenic mice model. We show that both Synphilin‐1 and α‐synuclein are toxic by themselves, but when co‐expressed, they suppress their toxicity reciprocally. Importantly, the symptoms induced in the fly can be treated and partially reverted using standard PD pharmacological treatments. This work showcases Drosophila as a detailed and multifaceted model for Parkinson's disease, providing a convenient platform in which to study and find new genetic modifiers of PD. genesis 49:392–402, 2011. © 2011 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Mexique</li></country></list><tree><country name="Mexique"><noRegion><name sortKey="Vargas, Rene Hernandez" sort="Vargas, Rene Hernandez" uniqKey="Vargas R" first="René Hernández-" last="Vargas">René Hernández- Vargas</name></noRegion><name sortKey="Escovar, Juan Riesgo" sort="Escovar, Juan Riesgo" uniqKey="Escovar J" first="Juan Riesgo-" last="Escovar">Juan Riesgo- Escovar</name><name sortKey="Gonzalez, Ignacio L Pez" sort="Gonzalez, Ignacio L Pez" uniqKey="Gonzalez I" first="Ignacio L Pez-" last="González">Ignacio L Pez- González</name><name sortKey="Ornelas, Luis Fonseca" sort="Ornelas, Luis Fonseca" uniqKey="Ornelas L" first="Luis Fonseca-" last="Ornelas">Luis Fonseca- Ornelas</name><name sortKey="Reynaud, Enrique" sort="Reynaud, Enrique" uniqKey="Reynaud E" first="Enrique" last="Reynaud">Enrique Reynaud</name><name sortKey="Zurita, Mario" sort="Zurita, Mario" uniqKey="Zurita M" first="Mario" last="Zurita">Mario Zurita</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000143 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000143 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:422509D73063BA42E12C834111AAF272F7C3E0C7
|texte= Synphilin suppresses α‐synuclein neurotoxicity in a Parkinson's disease Drosophila model
}}
| This area was generated with Dilib version V0.6.23. |  |